Periapical abscess precipitating diabetic ketoacidosis and reversible sepsis-induced cardiomyopathy: a case report - Summary - MDSpire

Diabetic Ketoacidosis and Reversible Sepsis-Induced Cardiomyopathy Triggered by a Periapical Abscess: A Case Study

  • By

  • Jixia Jin

  • Lian Liao

  • Yinhang Ren

  • Guiyun Li

  • Yuyang Qiu

  • July 15, 2026

Share

Objective:

To present a case of diabetic ketoacidosis (DKA) and sepsis-induced cardiomyopathy (SICM) triggered by a periapical abscess in a patient with poorly controlled diabetes, emphasizing the clinical implications of odontogenic infections.

Approach:
  • Management: The patient received early empiric antibiotics (amoxicillin-clavulanate and tinidazole), aggressive fluid resuscitation, and intravenous insulin infusion. Multidisciplinary source control was implemented.
Key Findings:
  • The patient had severe DKA with a pH of 7.04 and β-hydroxybutyrate of 7.19 mmol/L.
  • Echocardiography showed severe left ventricular systolic dysfunction (ejection fraction 36%) consistent with SICM.
  • Follow-up echocardiography on day 14 showed complete recovery of cardiac function (ejection fraction 72%).
  • The patient showed rapid clinical improvement, with metabolic acidosis and ketosis resolving and infection markers normalizing.
Interpretation:

Odontogenic infections can trigger DKA and septic shock in diabetic patients, necessitating thorough physical examinations.

Limitations:
  • The case is a single patient report, limiting generalizability.
  • Long-term outcomes beyond one month are not reported.
Conclusion:

The case illustrates the critical importance of recognizing odontogenic infections as potential triggers for severe DKA and SICM in diabetic patients.

Original Source(s)

Related Content