Using a Large Language Model to Support Thematic Analysis of Patient Experiences in Chronic Illness Management: Comparative Qualitative Study - Summary - MDSpire

Using a Large Language Model to Support Thematic Analysis of Patient Experiences in Chronic Illness Management: Comparative Qualitative Study

  • By

  • Sara Kivity

  • Yechiel Michael Barilan

  • Reut Noham

  • Mor Saban

  • June 29, 2026

  • 0 min

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Objective:

To evaluate the contribution of LLM-assisted analysis compared to traditional thematic analysis in chronic illness management.

Approach:
  • Study Design and Participants: The study employed thematic analysis within an interpretivist framework, conducting semistructured interviews with individuals managing multiple chronic conditions to identify recurring themes.
  • Phased Methodology: The study followed a multiphase qualitative approach, including the development of an interview guide, data collection through interviews, and comparative analysis of manual and AI-assisted thematic analysis.
Key Findings:
  • LLMs can identify patterns and generate thematic insights from large textual datasets.
  • LLM-assisted analysis may reveal alternative thematic groupings that challenge or complement researchers' assumptions.
  • The study's design allowed for a comparative evaluation of manual and LLM-assisted analysis.
Interpretation:

LLMs offer a scalable alternative to traditional qualitative analysis, potentially enhancing the depth and breadth of insights in chronic illness management research.

Limitations:
  • Manual thematic analysis is time-intensive and resource-demanding.
  • Variations in coding and interpretation may affect consistency in team-based settings.
Conclusion:

The study highlights the comparative evaluation of LLMs in qualitative research, particularly in the context of chronic illness management.

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