Association of DAPT duration with bleeding and ischemic outcomes after percutaneous coronary intervention with drug-coated balloons: a meta-analysis - Summary - MDSpire
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Impact of Dual Antiplatelet Therapy Duration on Bleeding and Ischemic Events Following Percutaneous Coronary Intervention with Drug-Coated Balloons: A Meta-Analysis

  • By

  • Giuseppe Panuccio

  • Nicole Carabetta

  • Martina Sportelli

  • Giuseppe Tartaglione

  • Kambis Mashayekhi

  • Emmanouil S. Brilakis

  • David M. Leistner

  • Sabato Sorrentino

  • Youssef Abdelwahed

  • Ulf Landmesser

  • Salvatore De Rosa

  • Daniele Torella

  • May 18, 2026

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Objective:

To define the current DAPT duration after DCB angioplasty and explore its association with bleeding and ischemic outcomes.

Key Findings:
  • DAPT duration after DCB angioplasty varies significantly across studies.
  • Shorter DAPT regimens may be associated with reduced bleeding complications without compromising ischemic protection.
  • No definitive optimal DAPT duration established due to variations in clinical practice.
Interpretation:

The findings suggest that shorter DAPT durations could be safe for patients undergoing DCB angioplasty, but further dedicated studies with larger sample sizes are needed to confirm these associations.

Limitations:
  • Lack of randomized evidence specifically addressing DAPT duration after DCB, which limits the strength of the conclusions.
  • Variability in DAPT reporting and definitions of clinical outcomes across studies.
Conclusion:

This meta-analysis highlights the need for further research to establish guidelines for DAPT duration following DCB angioplasty.

Original Source(s)

Association of DAPT duration with bleeding and ischemic outcomes after percutaneous coronary intervention with drug-coated balloons: a meta-analysis

  • by Giuseppe Panuccio, Nicole Carabetta, Martina Sportelli, Giuseppe Tartaglione, Kambis Mashayekhi, Emmanouil S. Brilakis, David M. Leistner, Sabato Sorrentino, Youssef Abdelwahed, Ulf Landmesser, Salvatore De Rosa, Daniele Torella

  • May 18, 2026

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