Objective:

To identify core risk factors and develop a simplified, externally validated nomogram for personalizing recurrence risk stratification in BPPV patients.

Approach:

Key Findings:

• 1-year recurrence rate was 23.97%, indicating a significant risk for patients.
• Nomogram included three core variables: Diabetes Mellitus (OR = 11.42), Non-posterior canal involvement (OR = 4.17), and 25-hydroxyvitamin D deficiency (OR = 3.76), highlighting critical risk factors.
• Model demonstrated good discrimination: AUC of 0.905 (training set), 0.872 (internal validation), and 0.853 (external validation).
• Calibration curves showed excellent agreement between predicted and observed probabilities.
• DCA and CIC confirmed significant net clinical benefit across a wide range of threshold probabilities.

Interpretation:

The developed nomogram integrates metabolic, anatomical, and nutritional markers for early identification of high-risk BPPV patients, aiding in personalized treatment strategies.

Limitations:

• Study limited to two medical centers, which may affect generalizability to broader populations.
• Retrospective design may introduce bias, limiting causal inferences.

Conclusion:

The nomogram facilitates targeted secondary prevention in clinical practice.

Source

Based on findings from:

Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study

Qiaozhi Jin, Ziyuan Chen, Yong Li, Yilong Wang, Changyu Duan, Yongjie Ying, Fude Jin. Frontiers In Neurology, 2026.

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1812718/full

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