Editorial: Unraveling protein misfolding and innate immunity in neurodegenerative diseases
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By
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Qianqian Fang
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Yinghui Hong
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Biyue Zhu
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May 28, 2026
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Objective:
To explore the interactions between protein misfolding, innate immunity, and their implications in neurodegenerative diseases (NDs).
Key Findings:
- Abnormal protein aggregates influence innate immune responses.
- Environmental factors, such as L-BMAA, can drive proteinopathies.
- AI can aid in understanding protein misfolding and immune interactions.
- Innate immune signatures may serve as clinical markers for organ damage.
Interpretation:
Limitations:
- The exact pattern recognition receptors for misfolded proteins remain unidentified.
- The long-term effects of the immune response in NDs are unclear.
Conclusion:
