Pediatric Anaphylaxis: Clinical Features and Identified Risk Factors for Severe Reactions from a Single-Center Study - Summary - MDSpire

Pediatric Anaphylaxis: Clinical Features and Identified Risk Factors for Severe Reactions from a Single-Center Study

  • By

  • Wenyu Wang

  • Yueyun Shang

  • Hui Zhang

  • Shuang Ba

  • Tongqiang Zhang

  • April 21, 2026

  • 0 min

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Objective:

To analyze clinical characteristics, severity, and risk factors for severe anaphylactic reactions in pediatric patients.

Key Findings:
  • Food was the most common trigger (62.61%).
  • Egg allergy was most prevalent in children under 1 year, while fruit allergy predominated in those over 6 years.
  • Antibiotic allergy was the most common drug-related trigger (44.44%).
  • Severe anaphylaxis was more prevalent in children over 6 years, males, and those with drug allergies.
  • Significant risk factors for severe anaphylaxis included male sex, age over 6, drug allergies, and short onset time, highlighting the need for targeted clinical attention.
Interpretation:

Food allergies are the primary triggers for anaphylaxis in children, with varying severity and allergen types based on age. Specific demographics are at higher risk for severe reactions, necessitating tailored clinical approaches.

Limitations:
  • Single-center study may limit generalizability and applicability to broader populations.
  • Retrospective design may introduce bias in data collection and analysis.
Conclusion:

Focused clinical attention is required for male children, those over 6 years old, and those with rapid-onset reactions due to their higher risk for severe anaphylaxis, emphasizing the need for proactive management strategies.

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