Response to Letter to the Editor From Lin et al: “Testosterone Treatment, Weight Loss, and Health-Related Quality of Life and Psychosocial Function in Men: A 2-Year Randomized Controlled Trial” - Summary - MDSpire

Response to Letter to the Editor From Lin et al: “Testosterone Treatment, Weight Loss, and Health-Related Quality of Life and Psychosocial Function in Men: A 2-Year Randomized Controlled Trial”

  • By

  • Mathis Grossmann

  • Kristy P Robledo

  • Mark Daniel

  • David J Handelsman

  • Warrick J Inder

  • Bronwyn G A Stuckey

  • Bu B Yeap

  • Mark Ng Tang Fui

  • Karen Bracken

  • Carolyn A Allan

  • David Jesudason

  • Jeffrey D Zajac

  • Gary A Wittert

  • January 30, 2025

  • 0 min

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Objective:

To address concerns raised by Lin et al regarding the effects of testosterone treatment on psychosocial outcomes in men with varying baseline testosterone levels.

Key Findings:
  • No interaction was found between baseline serum testosterone and psychosocial outcomes.
  • The effects of testosterone treatment on sexual function and quality of life were not related to baseline testosterone levels.
  • A potential small effect of testosterone treatment may have been overshadowed by the larger impact of the lifestyle program.
Interpretation:

The findings suggest that testosterone therapy's psychosocial benefits may not be significantly influenced by initial testosterone levels in the studied population.

Limitations:
  • Exclusion of men with pathological hypogonadism limits the generalizability of the findings.
  • The study may not capture the full spectrum of testosterone therapy effects in broader populations.
Conclusion:

The results highlight the importance of careful participant selection in testosterone studies and caution against extrapolating findings to men with pathological hypogonadism.

Original Source(s)

Response to Letter to the Editor From Lin et al: “Testosterone Treatment, Weight Loss, and Health-Related Quality of Life and Psychosocial Function in Men: A 2-Year Randomized Controlled Trial”

  • by Mathis Grossmann, Kristy P Robledo, Mark Daniel, David J Handelsman, Warrick J Inder, Bronwyn G A Stuckey, Bu B Yeap, Mark Ng Tang Fui, Karen Bracken, Carolyn A Allan, David Jesudason, Jeffrey D Zajac, Gary A Wittert

  • January 30, 2025

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