Long-Acting Injectable Antiretroviral Therapy in Medicare-Enrolled Adults With HIV - Summary - MDSpire

Long-Acting Injectable Antiretroviral Therapy in Medicare-Enrolled Adults With HIV

  • By

  • Jose F. Figueroa

  • Rebekah I. Stein

  • Jessica Phelan

  • E. John Orav

  • Grace Luu

  • Shibani S. Mukerji

  • Emily P. Hyle

  • June 12, 2026

  • 0 min

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Objective:

To quantify the use of long-acting injectable antiretroviral therapy (LA-ART) among Medicare beneficiaries with HIV and characterize differences in treatment patterns and outcomes between those receiving oral ART and LA-ART.

Key Findings:
  • Uptake of LA-ART was low, with only 3.0% of Medicare beneficiaries using it by 2023, highlighting a critical gap in treatment access.
  • Younger individuals (<55 years) were more likely to receive LA-ART compared to older individuals, indicating age-related disparities in treatment uptake.
  • American Indian or Alaska Native individuals were less likely to receive LA-ART than White individuals, reflecting racial disparities in access.
  • Beneficiaries with chronic conditions like Alzheimer disease and chronic kidney disease were less likely to receive LA-ART, suggesting treatment barriers for those with complex health needs.
  • Dual-eligible beneficiaries and those enrolled in Medicare Advantage were more likely to receive LA-ART, indicating the role of financial support in treatment access.
Interpretation:

The uptake of LA-ART among Medicare beneficiaries is uneven, with significant disparities based on age, race, and chronic conditions, reflecting broader issues in HIV care access that need to be addressed.

Limitations:
  • The study is descriptive and cannot establish causal relationships, limiting the understanding of treatment patterns.
  • Lack of clinical detail and inability to capture patient or physician-level factors affecting treatment choice may skew results.
  • Limited generalizability to individuals enrolled in Medicaid and commercial insurance may affect the applicability of findings.
Conclusion:

Early patterns suggest a need for targeted strategies to ensure equitable access to LA-ART, particularly for marginalized populations and older individuals with complex health needs, such as enhancing financial support and addressing systemic barriers.

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