To systematically evaluate the safety and clinical efficacy of porcine fibrin sealant (PFS) in VATS lobectomy for lung cancer.
Key Findings:
PFS shortened the duration of chest tube placement (P = 0.036).
PFS decreased the occurrence of pulmonary air leaks (0.0% vs. 5.0%, P = 0.019).
PFS reduced severely prolonged drainage (0.0% vs. 22.3%, P < 0.001).
No significant differences in other complications, and no allergic reactions occurred.
Interpretation:
The intraoperative application of PFS during VATS lobectomy is safe and effective in preventing postoperative pulmonary air leaks and reducing delayed chest tube removal.
Limitations:
The study was observational and not randomized.
The decision to use PFS was based on the operating surgeon's discretion.
Conclusion:
Intraoperative application of PFS during VATS lobectomy is associated with significant benefits in reducing complications related to chest tube drainage.
