Link Between Triglyceride Glucose–Body Mass Index and Nonunion Rates in Elderly Patients After Limb Fracture Surgery: A Multicenter Retrospective Analysis - Summary - MDSpire
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Link Between Triglyceride Glucose–Body Mass Index and Nonunion Rates in Elderly Patients After Limb Fracture Surgery: A Multicenter Retrospective Analysis
To investigate the association between triglyceride glucose–body mass index (TyG–BMI) and postoperative nonunion in older patients with limb fractures.
Key Findings:
Among 8,499 eligible patients, 141 cases (1.66%) developed nonunion.
RCS revealed a U-shaped relationship between TyG-BMI and nonunion, with risk thresholds at 173.9 and 213.0.
Both low (213.0) TyG-BMI levels were associated with increased nonunion risk (aOR 1.358 and 1.233, respectively).
Significant interactions were observed between TyG-BMI levels and perioperative blood transfusion and bone grafting type.
Interpretation:
TyG-BMI serves as a potential biomarker for risk stratification in older patients following limb fracture surgery, with both low and high levels indicating increased risk of nonunion.
Limitations:
Retrospective design may introduce bias.
Single-center data may limit generalizability.
Conclusion:
Both low and high TyG-BMI levels are significantly associated with increased nonunion risk, highlighting its potential role in individualized management of older fracture patients.
