To investigate trends in HPV-attributable cancers in men and women in Norway over the last 33 years, including the introduction of HPV vaccines, to inform future prevention strategies.
Key Findings:
HPV-attributable cancer incidence among men is rising, particularly for oropharyngeal SCC (annual percentage change [APC] 4.5).
Overall incidence of HPV-attributable cancers not prevented by screening increased (APC 2.8), surpassing cervical cancer incidence.
Cervical SCC incidence rates decreased by 6% annually from 2018 to 2023.
The burden of HPV-related cancers beyond cervical cancer is increasing in Norway.
Interpretation:
While cervical cancer incidence is declining due to screening and vaccination, other HPV-related cancers are on the rise, indicating a need for enhanced preventive measures, particularly for non-cervical cancers.
Limitations:
No early detection programs for non-cervical HPV-related cancers in Norway, which may hinder timely intervention.
Variability in HPV-attributable fractions across different cancer types and regions, complicating the assessment of overall burden.
Conclusion:
Addressing the increasing burden of HPV-attributable cancers, especially non-cervical types, requires additional preventive measures beyond cervical cancer screening.
