Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states

By
Clàudia Aymerich
Borja Pedruzo
Garazi Acasuso
Olatz Ibarretxe
Daniel Alonso-Alconada
Javier Labad
Maria José Algora
Ángel Cabezas
Gonzalo Salazar de Pablo
Miguel Ángel González-Torres
Vanessa Sanchez-Gistau
Ana Catalán
June 2, 2026
0 min

Frontiers In Psychiatry

Objective:

To investigate differences in neutrophil-to-lymphocyte ratio (NLR) across clinical high-risk for psychosis (CHR-P), first-episode psychosis (FEP), and healthy control (HC) populations, and to explore associations between NLR and demographic, clinical, and cognitive variables.

Key Findings:

Clarify that correlation results are adjusted for confounders.

Interpretation:

Remove unsupported claims about NLR as a diagnostic biomarker.

Limitations:

The sample size was relatively small, which may limit the generalizability of the findings.
The study did not establish causation between NLR and clinical features.

Conclusion:

Revise to avoid implications about NLR's potential roles without direct attribution.

Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states

Objective:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states

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