Factors Affecting Significant Breast Edema in Breast Cancer Patients Receiving Breast-Conserving Surgery and Radiotherapy with Deep Inspiration Breath Hold - Summary - MDSpire
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Factors Affecting Significant Breast Edema in Breast Cancer Patients Receiving Breast-Conserving Surgery and Radiotherapy with Deep Inspiration Breath Hold
To investigate factors associated with significant breast edema (SBE) during radiotherapy in breast cancer patients post-breast-conserving surgery, which may affect treatment outcomes.
Key Findings:
PTVboost volume was the only independent factor significantly associated with increased risk of SBE (OR = 1.072, 95% CI: 1.010-1.137, p = 0.022).
Optimal cutoff value of PTVboost volume for predicting SBE was determined to be 107.5 cc, with a sensitivity of 0.800 and specificity of 0.560.
Interpretation:
A larger PTVboost volume correlates with a higher probability of significant breast edema, which may impact treatment accuracy and patient quality of life, necessitating careful monitoring.
Limitations:
Retrospective design may introduce selection bias.
Single-institution study limits generalizability of findings.
The impact of the DIBH technique on SBE occurrence was not assessed.
Conclusion:
Increased attention to SBE is crucial in breast cancer patients undergoing radiotherapy, and proactive management is recommended to enhance treatment outcomes.
