To investigate synovial fluid levels of maresin-1 (MaR-1) and maresin-2 (MaR-2) in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), osteoarthritis (OA), and controls, and to assess their ability to differentiate PsA from RA.
Approach:
Study Design: Prospective cross-sectional study including 88 patients undergoing knee arthrocentesis for joint effusion.
Classification Criteria: RA classified according to 2010 ACR/EULAR criteria, PsA using CASPAR criteria, and OA based on clinical and radiographic assessment.
Measurement Method: Synovial fluid MaR-1 and MaR-2 concentrations measured by ELISA and expressed as ng/mL.
Statistical Analysis: Group comparisons using parametric or non-parametric tests; ROC curve analysis for diagnostic performance.
Key Findings:
MaR-2 showed more modest differences among groups (p < 0.05).
Interpretation:
Synovial MaR-1 concentrations were markedly elevated in PsA compared with RA.
Limitations:
The clinical significance of MaR-2 appears more limited and requires validation in larger studies.
Conclusion:
Maresin-1 levels may serve as a useful biomarker for differentiating PsA from RA.
