Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines - Summary - MDSpire
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Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines
To investigate the impact of chronic Hepatitis C virus (HCV) infection on bone microarchitecture and the role of inflammatory cytokines in bone deficits, highlighting the significance for patient management.
Key Findings:
Participants with chronic HCV had lower radius trabecular volumetric BMD (-24.2 mg HA/cm3, P < .05) and lower tibia trabecular volumetric BMD (-20.5 mg HA/cm3, P < .05).
Cortical area and thickness were also reduced in HCV participants (-20.9 mm2, P < .05 and -0.47 mm respectively, P < .05).
Mean log TNF-α was significantly higher in chronic HCV (+0.1-log pg/mL; P < .001).
Higher TNF-α levels correlated with lower trabecular and cortical BMD and increased cortical porosity (all P < .05).
Interpretation:
Chronic HCV infection is associated with significant deficits in trabecular and cortical bone microarchitecture, potentially mediated by elevated inflammatory cytokines, particularly TNF-α, with implications for clinical management.
Limitations:
Cross-sectional design limits causal inferences, necessitating caution in interpretation.
Study population may not be representative of all individuals with chronic HCV, affecting generalizability.
Conclusion:
Chronic HCV infection adversely affects bone microarchitecture, suggesting that inflammation may play a critical role in bone health among affected individuals, warranting further investigation into therapeutic strategies.
by Erica J Weinstein, Dean M Carbonari, Craig W Newcomb, Jessie Torgersen, Shanae M Smith, Katherine L Brecker, X Sherry Liu, Jay R Kostman, Stacey Trooskin, Rebecca A Hubbard, Joshua F Baker, Babette S Zemel, Mary B Leonard, Vincent Lo Re
