To assess the quality of evidence and estimate the rate of infection following colonization with specific multidrug-resistant gram-negative bacteria, including ESBL-E and CRE.
Key Findings:
The pooled incidence of infection following colonization was 22% for both ESBL-E and CRE, indicating a significant public health concern.
Few reviews provided high-quality findings on mortality or transmission related to colonization, highlighting a gap in the literature.
Limited data were available for MDR Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii, suggesting a need for further research.
Interpretation:
The findings indicate a significant rate of infection following colonization with MDR-GNB, underscoring the need for improved patient counseling and innovative decolonization strategies to mitigate risks.
Limitations:
Heterogeneity of included populations may limit generalizability.
Few high-quality studies on mortality and transmission were available, and potential biases in the included studies may affect the results.
Conclusion:
The study underscores the substantial infection risk associated with MDR-GNB colonization, which can inform clinical practices and future research.
by Edwin Wilbur Woodhouse, Majd Alsoubani, David J Roach, David B Flynn, Michael LaValley, Kristen Sheridan, David C Hooper, Vance G Fowler, Erin M Duffy, Trudy H Grossman
A VHA study across 11 vendors finds AI-generated primary care notes score lower than clinician-written notes, with the largest deficits in thoroughness, organization, and usefulness
