Arrhythmic risk stratification in patients with left ventricular ring-like scar - Summary - MDSpire

Arrhythmic risk stratification in patients with left ventricular ring-like scar

  • By

  • Vanda Parisi

  • Maddalena Graziosi

  • Luis R Lopes

  • Antonio De Luca

  • Ferdinando Pasquale

  • Giacomo Tini

  • Mattia Targetti

  • Maria R Cueto

  • Ana R Moura

  • Raffaello Ditaranto

  • Camilla Torlasco

  • Nevio Taglieri

  • Elena Nardi

  • Luigi Lovato

  • João B Augusto

  • Nazzareno Galiè

  • Lia Crotti

  • Alessio Gasperetti

  • Mauro Biffi

  • Camillo Autore

  • Marco Merlo

  • Iacopo Olivotto

  • Gianfranco Sinagra

  • Perry M Elliott

  • Elena Biagini

  • November 1, 2024

  • 0 min

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Objective:

To evaluate the LV ring-like scar phenotype and identify specific risk factors for life-threatening arrhythmic events (LAEs) in patients with non-ischaemic cardiomyopathy.

Key Findings:
  • Survival free from LAEs was 60% (3.8 events/100 patients/year); at median follow-up, it was 84%, highlighting the significance of these findings.
  • Independent risk factors for LAEs included anterior Q waves, QRS width, and LV end-diastolic volume index (LVEDVi), with statistical significance.
  • Three risk categories identified based on ECG findings correlated with decreasing survival rates, emphasizing clinical implications.
Interpretation:

The LV ring-like scar phenotype is associated with a high rate of malignant arrhythmias, particularly in the presence of specific ECG abnormalities and increased LV volumes, underscoring the importance of these factors in clinical risk stratification.

Limitations:
  • Retrospective design may introduce selection bias, potentially affecting the reliability of the findings.
  • Limited generalizability due to multicentre nature and specific inclusion criteria, which may not represent the broader population.
Conclusion:

The study highlights the importance of ECG abnormalities and LV volumes in stratifying arrhythmic risk in patients with LV ring-like scars, suggesting areas for future research.

Original Source(s)

Arrhythmic risk stratification in patients with left ventricular ring-like scar

  • by Vanda Parisi, Maddalena Graziosi, Luis R Lopes, Antonio De Luca, Ferdinando Pasquale, Giacomo Tini, Mattia Targetti, Maria R Cueto, Ana R Moura, Raffaello Ditaranto, Camilla Torlasco, Nevio Taglieri, Elena Nardi, Luigi Lovato, João B Augusto, Nazzareno Galiè, Lia Crotti, Alessio Gasperetti, Mauro Biffi, Camillo Autore, Marco Merlo, Iacopo Olivotto, Gianfranco Sinagra, Perry M Elliott, Elena Biagini

  • November 1, 2024

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