The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party - Summary - MDSpire

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

  • By

  • Lars Klingen Gjærde

  • Tapani Ruutu

  • Christophe Peczynski

  • William Boreland

  • Nicolaus Kröger

  • Didier Blaise

  • Thomas Schroeder

  • Régis Peffault de Latour

  • Tobias Gedde-Dahl

  • Aleksandr Kulagin

  • Henrik Sengeløv

  • Ibrahim Yakoub-Agha

  • Jürgen Finke

  • Matthias Eder

  • Grzegorz Basak

  • Ivan Moiseev

  • Hélène Schoemans

  • Christian Koenecke

  • Olaf Penack

  • Zinaida Perić

  • December 7, 2023

  • 0 min

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Objective:

To assess the impact of pre-transplantation diabetes and obesity on the incidence of acute graft-versus-host disease (GvHD), relapse, and mortality after allogeneic hematopoietic cell transplantation (HCT), highlighting its significance in improving patient outcomes.

Key Findings:
  • Obesity was associated with increased non-relapse mortality (NRM) in some studies, but findings on acute GvHD were inconsistent across various studies.
Interpretation:

The study suggests that while pre-transplantation diabetes and obesity are prevalent, their impact on acute GvHD incidence remains unclear, necessitating larger studies for conclusive evidence, particularly in diverse patient populations.

Limitations:
  • The low prevalence of pre-transplantation diabetes and obesity limits the statistical power of the findings.
  • Data primarily from patients transplanted before 2010 may not reflect current practices and patient demographics, and the retrospective nature may introduce biases.
Conclusion:

Further large-scale registry studies are needed to clarify the effects of obesity and diabetes on acute GvHD and related mortality in allogeneic HCT patients, particularly focusing on the evolving patient demographics and treatment modalities.

Original Source(s)

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

  • by Lars Klingen Gjærde, Tapani Ruutu, Christophe Peczynski, William Boreland, Nicolaus Kröger, Didier Blaise, Thomas Schroeder, Régis Peffault de Latour, Tobias Gedde-Dahl, Aleksandr Kulagin, Henrik Sengeløv, Ibrahim Yakoub-Agha, Jürgen Finke, Matthias Eder, Grzegorz Basak, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Olaf Penack, Zinaida Perić

  • December 7, 2023

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