Clinical manifestations and outcomes of fetal periventricular pseudocysts: a study of 38 cases - Summary - MDSpire

Clinical manifestations and outcomes of fetal periventricular pseudocysts: a study of 38 cases

  • By

  • Jing Ding

  • YiHan Xiao

  • Jie Fu

  • Jia Liu

  • Yifang Yuan

  • Qiuyan Pei

  • July 13, 2026

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Objective:

To describe the clinical manifestations and enhance the understanding of outcomes linked to fetal periventricular pseudocysts.

Approach:
  • Study Design: Retrospective evaluation of 38 pregnant women diagnosed with fetal periventricular pseudocysts between January 2015 and May 2025.
  • Diagnosis: Diagnosis was confirmed through fetal ultrasound and, in some cases, MRI.
  • Monitoring: 15 pseudocysts were closely monitored for changes in size during pregnancy.
Key Findings:
  • Most diagnoses occurred in the third trimester, with 33 out of 38 cases.
  • Over two-thirds of the pseudocysts were bilateral, primarily located on the lateral aspect of the anterior horn of the lateral ventricle.
  • Three fetuses had genetic or chromosomal abnormalities.
  • Two newborns required NICU admission due to infection and prematurity.
  • Two of the 34 newborns exhibited developmental delays in language and/or motor domains.
Interpretation:

Most fetal periventricular pseudocysts were associated with favorable outcomes, except in cases with additional abnormalities.

Limitations:
  • Small sample size of 38 cases.
  • Retrospective nature may limit comprehensive data collection.
Conclusion:

Fetal periventricular pseudocysts are predominantly detected in later trimesters and are often associated with favorable outcomes, particularly when isolated.

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