Compare 30-day surgical site infection (SSI) incidence with versus without pre-incision cefazolin and assess perioperative factors associated with SSI after laparoscopic adnexal surgery for benign disease.
Approach:
Design and setting: Multicenter retrospective cohort using a prospectively maintained database from Osaka University and six affiliated Japanese hospitals; eligible operations occurred from January 2020 through December 2023.
Participants and comparison: Included consecutive patients undergoing laparoscopic adnexal surgery for benign indications. Compared patients given pre-incision cefazolin with patients receiving no prophylactic antibiotics; antibiotic practice followed each hospital’s policy.
Outcomes and analysis: The primary outcome was CDC-defined SSI within 30 days. Analyses included group comparisons, logistic regression, and inverse probability of treatment weighting based on selected clinical covariates.
Key Findings:
The provided context describes the study rationale, methods, and planned analyses but does not report results or SSI incidence.
Interpretation:
The study was designed to evaluate whether cefazolin prophylaxis was associated with lower 30-day SSI incidence and to identify factors associated with SSI; the supplied material does not establish the findings.
Limitations:
Retrospective observational design, with antibiotic use determined by participating hospital policy.
No formal sample size calculation was performed.
SSI events were anticipated to be few, so multivariable models were restricted to limit overfitting.
Smoking, immunocompromised status, and nutritional status were not consistently recorded across institutions.
