Objective:

To analyze the clinical features and diagnostic challenges of cutaneous squamous cell carcinoma arising from chronic limb wounds, known as Marjolin ulcers.

Approach:

Key Findings:

• All patients were initially misdiagnosed with benign chronic wounds, leading to diagnostic delays ranging from months to decades.
• Final surgical pathology confirmed cutaneous squamous cell carcinoma in every case, with bone invasion in two cases.
• Treatment escalated from potentially curative local excision to amputation in three of the four cases.
• No local recurrence was detected during the short-term follow-up period.

Interpretation:

Limitations:

• The study is based on a small sample size of four cases.
• Findings may not be generalizable to all populations or settings.

Conclusion:

A practical set of clinical warning signals is proposed, focusing on wound chronicity and abnormal morphology.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.