Most common, burdensome, and worrisome symptoms experienced by people living with early Parkinson’s disease in Germany and the United States—Results from a cross-sectional survey - Summary - MDSpire

Most common, burdensome, and worrisome symptoms experienced by people living with early Parkinson’s disease in Germany and the United States—Results from a cross-sectional survey

  • By

  • Simon Messner

  • Àngels Costa

  • Todd Carmody

  • Rebekah Park

  • Byron Jones

  • Elisabeth Lucassen

  • Amelia Hursey

  • July 8, 2026

  • 0 min

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Objective:

To identify the most common, burdensome, and worrisome symptoms of early-stage Parkinson’s disease (ePD).

Approach:
  • Study Design: Descriptive, cross-sectional study using an online survey completed by individuals with ePD in the US and Germany.
  • Survey Development: The survey included questions on common symptoms, burdensome symptoms, and worrisome symptoms, developed with input from patient advocacy organizations.
Key Findings:
  • All respondents reported experiencing tremor, mobility issues, and pain as the most burdensome symptoms.
  • Bradykinesia, mobility issues, memory loss, cognitive impairment, and urinary and gastrointestinal problems were reported with a frequency of at least 30% higher in the 4–5-year post-diagnosis group.
Interpretation:

Limitations:
  • The study focused on self-reported symptoms, which may be subject to bias.
  • Limited generalizability due to the specific populations surveyed in the US and Germany.
Conclusion:

Original Source(s)

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