Bilateral atrial appendage thrombosis in light chain cardiac amyloidosis: a case report - Summary - MDSpire

Bilateral atrial appendage thrombosis in light chain cardiac amyloidosis: a case report

  • By

  • Haiyan Jia

  • Shengqi Jia

  • Weifeng Zhang

  • Zepeng Ma

  • Xiaomin Meng

  • July 15, 2026

Share

Objective:

To report a case of light chain cardiac amyloidosis with bilateral atrial appendage thrombosis and its clinical course.

Approach:
  • Case Presentation: A 70-year-old woman with a history of progressive exertional dyspnea and recurrent syncope was diagnosed with light chain cardiac amyloidosis and bilateral atrial appendage thrombosis.
  • Diagnostic Evaluation: The patient underwent various diagnostic tests including echocardiography, cardiac MRI, and CT angiography, which confirmed the presence of cardiac amyloidosis and thrombi.
  • Treatment: The patient was treated with anticoagulation, heart failure medications, and a pacemaker, but declined chemotherapy due to financial constraints.
  • Follow-up: Follow-up via telephone indicated initial improvement, but the patient later discontinued medications and died from refractory heart failure.
Key Findings:
  • The patient exhibited bilateral atrial appendage thrombosis associated with light chain cardiac amyloidosis.
  • Despite initial treatment, the patient experienced rapid clinical deterioration and ultimately died from refractory heart failure.
Interpretation:

This case illustrates the challenges in managing complications associated with light chain cardiac amyloidosis.

Limitations:
  • No repeat imaging was performed during follow-up, which limited the assessment of the patient's condition.
  • Follow-up assessments were conducted via telephone, limiting clinical evaluation.
Conclusion:

This case highlights the need for early recognition and intervention in light chain cardiac amyloidosis.

Original Source(s)

Related Content