Objective:

To assess and compare the long-term outcomes of patients undergoing Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy (SADI-S) versus Biliopancreatic Diversion with Duodenal Switch (BPD/DS), highlighting the significance of this comparison in clinical practice.

Key Findings:

• Both SADI-S and BPD/DS showed comparable weight loss and resolution of obesity-related conditions, with specific data to be included.
• SADI-S had a lower expected risk of long-term nutritional deficiencies due to a longer common channel, supported by data.
• Postprandial endocrine responses differed, with SADI-S eliciting higher GLP-1 release, indicating potential metabolic advantages.

Interpretation:

The findings suggest that SADI-S may offer similar weight loss outcomes with potentially reduced nutritional risks compared to BPD/DS, emphasizing the need for further long-term studies to confirm these benefits and their implications for patient care.

Limitations:

• Lack of direct long-term comparisons between SADI-S and BPD/DS, which limits the generalizability of the findings.
• Retrospective design may introduce selection bias, affecting the reliability of the outcomes.

Conclusion:

SADI-S may be a viable alternative to BPD/DS with comparable outcomes and potentially lower nutritional risks, warranting further investigation to validate these findings.