Objective:

To describe and compare the variations in cytokines IL-2, IL-6, IL-10, TNF-α, and IFN-γ in DENV, CHIKV, ZIKV, and MAYV infections in northeastern Peru.

Approach:

Key Findings:

• Distinct cytokine profiles were observed for each arbovirus.
• Elevations in IL-10 and IFN-γ were linked to dengue severity.
• ZIKV infection showed increased levels of IFN-γ, IL-1ra, IL-7, IL-9, and RANTES.
• MAYV infections were associated with significant pro-inflammatory cytokine expressions.

Interpretation:

The study highlights the importance of cytokine profiles in differentiating arboviral infections, which can aid in diagnosis and management in endemic regions.

Limitations:

• The study was limited to a specific geographic region and may not be generalizable.
• Sample size for each group was relatively small (20 patients each).

Conclusion:

Characterizing cytokine profiles can enhance diagnostic accuracy and clinical outcomes for arboviral diseases in regions like Peru.

Source

Based on findings from:

Cytokine Dynamics During Acute Infections of Dengue, Zika, Chikungunya, and Mayaro Viruses in Northern Peru

Juana del Valle-Mendoza, Hugh Watson, Yordi Tarazona-Castro, Wilmer Silva-Caso, Ronald Aquino-Ortega, Hugo Carrillo-Ng, Jorge Bazan-Mayra, Victor Zavaleta-Gavidia, Miguel Angel Aguilar-Luis. Bmc Infectious Diseases, 2026.

https://link.springer.com/article/10.1186/s12879-026-12537-x

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This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.