To provide pooled estimates of dementia with Lewy bodies (DLB) incidence and prevalence, and to examine variations according to age, geographic region, and methodological approach.
Approach:
Study Inclusion Criteria: Included population-based studies reporting DLB incidence or prevalence using validated diagnostic criteria, excluding editorials and studies lacking empirical data.
Data Extraction: Three reviewers independently extracted study data using a standardized form, including study characteristics and incidence/prevalence data.
Quality Assessment: Quality of studies was reviewed using the Newcastle-Ottawa Scale and Joanna Briggs Institute Critical Appraisal Checklist.
Statistical Analysis: Pooled estimates of incidence and prevalence were calculated using random-effects generalized linear mixed models.
Key Findings:
DLB is the second most common cause of degenerative dementia after Alzheimer's disease.
DLB presents with cognitive decline, fluctuations in cognition, visual hallucinations, REM sleep behavior disorder, and parkinsonism.
DLB is associated with higher mortality and greater health care utilization compared to Alzheimer's disease.
Interpretation:
Limitations:
Global incidence and prevalence of DLB remain poorly defined.
Variability in diagnostic criteria and study designs may affect the comparability of results.
Conclusion:
This systematic review and meta-analysis aims to fill the knowledge gap regarding the global burden of DLB.
