Pagetoid reticulosis (Woringer–Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review - Summary - MDSpire
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Pagetoid reticulosis (Woringer–Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review
To report a case of Pagetoid reticulosis (PR) misdiagnosed as eczema and to review existing literature on its clinical and immunophenotypic features, emphasizing the importance of accurate diagnosis.
Approach:
Case Report: A 53-year-old female with a 5-year history of a pruritic erythematous plaque on the right ankle was evaluated. Initial mismanagement as chronic eczema led to a diagnostic biopsy, which confirmed Pagetoid reticulosis.
Key Findings:
Pagetoid reticulosis is often misdiagnosed due to its non-specific clinical presentation.
Histopathological features include epidermotropic infiltration of atypical lymphocytes.
Immunophenotypic evaluation is crucial for accurate diagnosis and treatment planning, highlighting the variability in clinical presentation.
Interpretation:
Localized Woringer–Kolopp disease has variable clinical and immunophenotypic features, and timely diagnosis is essential for effective treatment.
Limitations:
The rarity of PR limits the amount of available evidence, impacting clinical understanding and management.
Conclusion:
Early biopsy and immunophenotypic evaluation are essential to avoid diagnostic delays and guide treatment.
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