Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD - Summary - MDSpire

Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD

  • By

  • Tao Qin

  • Wenlong Huang

  • Changwei Yang

  • Tianming Lu

  • Jun Wang

  • Jie Chen

  • Linli Chen

  • Tianyu Yan

  • Tingting Qian

  • Hao Yang

  • Linke Lu

  • Defa Huang

  • Minghong Zhao

  • June 19, 2026

  • 0 min

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Objective:

To delineate the distinct immunometabolic perturbations in HIV-associated acute exacerbation of chronic obstructive pulmonary disease (HIV-AECOPD) and to identify circulating biomarkers predictive of short-term prognosis.

Approach:
    Key Findings:
    • CRP emerged as the most important predictor of poor 3-month prognosis with an AUC of 0.8125 (95% CI: 0.628–0.997) and a Random Forest Mean Decrease Gini of 1.33.
    Interpretation:

    Conclusion:

Original Source(s)

Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD

  • by Tao Qin, Wenlong Huang, Changwei Yang, Tianming Lu, Jun Wang, Jie Chen, Linli Chen, Tianyu Yan, Tingting Qian, Hao Yang, Linke Lu, Defa Huang, Minghong Zhao

  • June 19, 2026

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