To determine the timepoint of onset of lower urinary tract symptoms (LUTS) in patients with multiple sclerosis (PwMS) and identify risk factors for early development of LUTS, emphasizing the importance of these factors in clinical management.
Key Findings:
The prevalence of LUTS in the cohort was 61%, with statistical significance noted.
The most frequently reported first LUTS was urgency (51%, p-value).
Median LUTS-free survival time was 8 years post-MS diagnosis.
LUTS-free survival rates were 60% at 5 years, 45% at 10 years, and 20% at 20 years.
Higher age, higher EDSS, presence of CPS, and occurrence of OCB were associated with shorter LUTS-free survival (p-values).
Interpretation:
LUTS are common in PwMS, significantly impacting quality of life. Early identification and management of LUTS may be crucial in MS care, suggesting a need for proactive strategies.
Limitations:
The study was retrospective and conducted at a single center, which may limit generalizability and the applicability of findings to broader populations.
Potential recall bias in patient-reported onset of LUTS.
Conclusion:
LUTS develop frequently and early in the course of MS, with specific risk factors influencing their onset. Awareness and proactive management of LUTS in MS patients are essential.
