Hybrid Management of Subclavian-Axillary Artery Aneurysms in Loeys-Dietz Syndrome After Prior Aortic Arch Repair: Technical Note - Summary - MDSpire

Hybrid Management of Subclavian-Axillary Artery Aneurysms in Loeys-Dietz Syndrome After Prior Aortic Arch Repair: Technical Note

  • By

  • George Apostolidis

  • Tilo Kölbel

  • Petroula Nana

  • Jose I. Torrealba

  • Meike Rybczynski

  • Giuseppe Panuccio

  • June 30, 2026

  • 0 min

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Objective:

To describe a hybrid technique combining endovascular stent-graft implantation with open distal anastomosis for managing subclavian-axillary artery aneurysms in patients with Loeys-Dietz syndrome.

Approach:
  • Case 1 Presentation: A 42-year-old man with Loeys-Dietz syndrome underwent a two-staged approach for aortic arch repair and right subclavian artery aneurysm, utilizing a Frozen Elephant Trunk repair followed by a hybrid approach for the aneurysm.
  • Case 2 Presentation: A 63-year-old woman with extensive aneurysmal disease had a hybrid approach for aortic arch and left subclavian artery aneurysm repair, involving branched endovascular aortic arch repair and TEVAR.
Key Findings:
  • Both cases utilized a hybrid surgical approach to manage complex aneurysms in patients with Loeys-Dietz syndrome.
  • The hybrid technique allowed for targeted exclusion of aneurysmal segments while minimizing the physiological burden of open surgery.
Interpretation:

The hybrid approach may provide a viable option for managing subclavian-axillary artery aneurysms in high-risk patients with Loeys-Dietz syndrome.

Limitations:
  • The evidence regarding the safety, efficacy, and long-term outcomes of hybrid approaches in managing subclavian-axillary artery aneurysms in Loeys-Dietz syndrome is limited.
Conclusion:

The described hybrid technique demonstrates a potential strategy for managing complex aneurysms in patients with Loeys-Dietz syndrome, although further evidence is needed.

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