Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model - Summary - MDSpire
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Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model
To identify risk factors for hemorrhagic transformation (HT) after mechanical thrombectomy (MT) in patients with acute anterior circulation large vessel occlusion (LVO) and to develop a predictive nomogram.
Key Findings:
Six independent risk factors for HT were identified: history of alcohol consumption, history of leukoencephalopathy, elevated blood glucose-to-lymphocyte ratio (GLR), elevated D-dimer, elevated venous blood glucose, and reduced mean platelet volume (MPV).
The nomogram demonstrated an AUC of 0.880, sensitivity of 0.933, and specificity of 0.696.
Calibration curve analysis indicated good model fit.
Interpretation:
The constructed nomogram provides a reliable tool for individualized risk prediction of HT after MT in acute anterior circulation LVO stroke.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
The requirement for informed consent was waived, which may raise ethical considerations.
Conclusion:
The identified risk factors and the developed nomogram can aid in predicting hemorrhagic transformation following mechanical thrombectomy.
