Dosimetric and clinical outcomes of stereotactic body radiotherapy for primary lung cancer: isocenter-based vs. volume-based prescription - Summary - MDSpire

Dosimetric and clinical outcomes of stereotactic body radiotherapy for primary lung cancer: isocenter-based vs. volume-based prescription

  • By

  • Mitsuru Okubo

  • Tomohiro Itonaga

  • Tatsuhiko Zama

  • Ryuji Mikami

  • Yukinori Okada

  • Tsubasa Kawamoto

  • Shiho Wada

  • Shinji Sugahara

  • Kazuhiro Saito

  • May 18, 2026

  • 0 min

Share

Objective:

To compare dosimetric and clinical outcomes of isocenter-based versus volume-based dose prescriptions in SBRT for early-stage NSCLC.

Key Findings:
  • 1
Interpretation:

Volume-based SBRT prescriptions provide superior dosimetric quality and clinical outcomes without increasing the risk of pulmonary toxicity, highlighting the need for clinical adoption.

Limitations:
  • Retrospective design may introduce selection bias.
  • Limited follow-up duration for some patients.
Conclusion:

Volume-based prescription is recommended for SBRT in early-stage NSCLC due to enhanced efficacy and safety.

Original Source(s)

Dosimetric and clinical outcomes of stereotactic body radiotherapy for primary lung cancer: isocenter-based vs. volume-based prescription

  • by Mitsuru Okubo, Tomohiro Itonaga, Tatsuhiko Zama, Ryuji Mikami, Yukinori Okada, Tsubasa Kawamoto, Shiho Wada, Shinji Sugahara, Kazuhiro Saito

  • May 18, 2026

Related Content

Editorial: Discovery of small molecule lead compounds: a driving force to unravel new anti-cancer targets and mechanisms, volume III

Machine learning–based prediction of mortality in lung cancer: Application of severity-adjustment method

Outcomes of robotic anatomic lung resection after neoadjuvant therapy for non-small cell lung cancer