Case Report: Presenting as optic neuritis—a biopsy-proven IgG4 anti-NF155–positive combined central and peripheral demyelination syndrome - Summary - MDSpire

Case Report: Presenting as optic neuritis—a biopsy-proven IgG4 anti-NF155–positive combined central and peripheral demyelination syndrome

  • By

  • Yujing Peng

  • Xiaonan Wang

  • Weijiao Zhang

  • Ran Li

  • Jingting Peng

  • Jiawei Wang

  • Hanqiu Jiang

  • May 22, 2026

  • 0 min

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Objective:

To report a case of a young male with optic neuritis as the initial manifestation of biopsy-confirmed IgG4 anti-NF155-positive combined central and peripheral demyelination syndrome (CCPD).

Key Findings:
  • The patient tested positive for IgG4 anti-NF155 antibodies.
  • Initial symptoms included severe optic neuritis and subsequent lower limb weakness.
  • Histopathological examination confirmed the diagnosis of CCPD.
Interpretation:

Remove unsupported conclusions and focus on case details.

Limitations:
  • The study is based on a single case report, limiting generalizability.
  • Long-term outcomes and responses to treatment in this patient are not fully detailed.
Conclusion:

Revise to eliminate unsupported claims about awareness and testing.

Original Source(s)

Case Report: Presenting as optic neuritis—a biopsy-proven IgG4 anti-NF155–positive combined central and peripheral demyelination syndrome

  • by Yujing Peng, Xiaonan Wang, Weijiao Zhang, Ran Li, Jingting Peng, Jiawei Wang, Hanqiu Jiang

  • May 22, 2026

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