Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause
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By
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Zhanfeng Zhang
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Jianyou Li
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Kuan Ni
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Chengyin Lei
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Xining Li
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Yunliang Yao
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June 1, 2026
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Objective:
To identify key genes linking immune cells and autophagy in postmenopausal osteoporosis (PMO) and construct a diagnostic model.
Key Findings:
- Three hub genes (CDK2, DDIT3, MAPK8) were identified.
- The diagnostic model exhibited high predictive accuracy (AUC = 0.91).
- CDK2 and DDIT3 were associated with ligand-receptor interaction pathways.
- Hub genes correlated significantly with altered immune cell infiltration.
- scRNA-seq highlighted bone marrow mesenchymal stem cells (BM MSCs) as a key site.
Interpretation:
Limitations:
- The study primarily relied on bioinformatics approaches.
- The sample size for some analyses may limit the generalizability of the findings.
Conclusion:
