To evaluate changes in cognitive function following COVID-19 in individuals with baseline pre-infectious cognitive assessments, focusing on the comparison between COVID+ and COVID- groups.
Key Findings:
Memory scores in the COVID+ group improved by +3.9 (P = .03).
The COVID- group showed overall improvements in Cognivue® score (+2; P = .03) and specific cognitive domains, including visuospatial (+1.9; P = .04), executive function (+2.2; P = .02), and naming language (+2.2; P = .01).
No significant differences in cognitive scores between COVID+ and COVID- groups.
Interpretation:
In a cohort with an average age of 45, no decrease in cognitive function was observed one year after COVID-19 infection in the COVID+ group.
Limitations:
Small sample size may limit generalizability.
Participants were relatively young and healthy, potentially skewing results and limiting applicability to broader populations.
Conclusion:
This study suggests that COVID-19 infection does not lead to long-term cognitive decline in a middle-aged population.
