Objective:

To evaluate serial bias in working memory among patients with schizophrenia, bipolar disorder with a history of psychosis, and healthy controls.

Approach:

Key Findings:

• Patients with schizophrenia exhibited a repulsive serial bias in working memory.
• Patients with bipolar disorder showed a mixed bias pattern, leaning towards the attractive bias seen in healthy controls.
• Healthy controls displayed an attractive bias with no instances of repulsive bias.
• Patients with schizophrenia had lower working memory precision compared to both bipolar disorder patients and healthy controls.
• No significant association was found between antipsychotic medication dose and serial bias.

Interpretation:

The findings suggest fundamental differences in how recent experiences impact working memory in schizophrenia compared to bipolar disorder and healthy individuals, with potential neurobiological implications.

Limitations:

• Limited cognitive measures collected, restricting subgroup characterization.
• All schizophrenia patients were on antipsychotic treatment, raising questions about medication-naive populations.
• Need for larger samples and alternative analytic approaches for deeper insights.

Conclusion:

Serial bias may serve as a biomarker for treatment development, highlighting the importance of targeting biologically defined subgroups in precision medicine.

Sources:

• JAMA Psychiatry
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