To assess the relationship between maternal prenatal exposure to NSAIDs and the risk of kidney disease in children, addressing the existing lack of consensus.
Key Findings:
Adjusted analysis showed a stronger association (OR 2.40 [1.84–3.13]), indicating the importance of considering confounding factors.
Interpretation:
The findings suggest a potential link between maternal NSAID use during pregnancy and increased risk of kidney disease in offspring, although causality remains uncertain due to potential confounding factors, such as maternal health and environmental influences.
Limitations:
Potential confounding by other risk factors, such as maternal health conditions and environmental exposures, was not fully addressed.
Conclusion:
This meta-analysis provides evidence of an association between prenatal NSAIDs exposure and kidney diseases in children, highlighting the urgent need for further high-quality studies to clarify causality.
