To analyze the association of axial length to corneal curvature radius ratio (AL/CR) and other ocular biometric parameters with myopia in children and adolescents, specifically those aged 6 to 12 years.
Key Findings:
Axial length and AL/CR increased with age, while spherical equivalent decreased.
Corneal curvature radius did not change significantly with age.
The correlation coefficients between AL/CR and spherical equivalent were -0.865, and between axial length and spherical equivalent were -0.747.
AL/CR showed a stronger correlation with spherical equivalent than axial length.
The area under the receiver operating characteristic curve for AL/CR was 0.938, higher than axial length at 0.87.
A total of 2,760 eyes (right eye) of 2,760 children and adolescents were included.
Interpretation:
AL/CR can independently reflect dynamic changes in spherical equivalent during myopia progression, making it a valuable parameter for assessing myopia in children and highlighting its implications for early detection and intervention.
Limitations:
The study was conducted at a single center, which may limit generalizability and introduce potential biases.
The cross-sectional design does not allow for causal inferences.
Conclusion:
The study supports the use of AL/CR as a predictive tool for myopia in pediatric populations, highlighting its potential for early detection and intervention, while also emphasizing the need for further research to validate these findings.
