To explore innovative treatment options for patients with structural disorders of the vocal folds.
Approach:
Multidisciplinary Care: The USC Voice Center integrates medical, surgical, and behavioral therapies to address complex vocal fold disorders.
Regenerative Medicine: Utilization of autologous platelet-rich plasma (PRP) injections and decellularized allograft adipose matrix for vocal fold scar and atrophy.
Immunotherapy for RRP: Introduction of Papzimeos, an FDA-approved immunotherapy for recurrent respiratory papillomatosis (RRP), to reduce the need for surgical interventions.
Key Findings:
PRP injections showed clinically meaningful improvements in voice quality for patients with vocal fold scar.
Decellularized allograft adipose matrix demonstrated safety and efficacy in treating vocal fold paralysis.
Papzimeos achieved a complete response in over 51% of patients requiring frequent surgeries for RRP.
Limitations:
The article does not provide detailed statistical data on the success rates of all treatments.
Long-term outcomes of the new therapies are not discussed.
Review of 88 studies found AI systems achieved high accuracy for identifying abnormal voices, but performance declined among higher-level laryngeal disorder classifications.
