Assessing Clinical Improvement of Infants Hospitalized for Respiratory Syncytial Virus–Related Critical Illness - Summary - MDSpire
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Evaluating Clinical Outcomes in Infants Admitted for Severe Respiratory Syncytial Virus Infections

  • By

  • Shannon B Leland

  • Laura D Zambrano

  • Steven J Staffa

  • Elizabeth R McNamara

  • Margaret M Newhams

  • Natasha Halasa

  • Justin Z Amarin

  • Laura S Stewart

  • Steven L Shein

  • Christopher L Carroll

  • Julie C Fitzgerald

  • Marian G Michaels

  • Katherine Bline

  • Melissa L Cullimore

  • Laura Loftis

  • Vicki L Montgomery

  • Asumthia S Jeyapalan

  • Pia S Pannaraj

  • Adam J Schwarz

  • Natalie Z Cvijanovich

  • Matt S Zinter

  • Aline B Maddux

  • Melania M Bembea

  • Katherine Irby

  • Danielle M Zerr

  • Joseph D Kuebler

  • Christopher J Babbitt

  • Mary G Gaspers

  • Ryan Nofziger

  • Michele Kong

  • Bria M Coates

  • Jennifer E Schuster

  • Shira J Gertz

  • Elizabeth H Mack

  • Benjamin R White

  • Helen Harvey

  • Charlotte V Hobbs

  • Heda Dapul

  • Andrew D Butler

  • Tamara T Bradford

  • Courtney M Rowan

  • Kari Wellnitz

  • Mary Allen Staat

  • Cassyanne L Aguiar

  • Saul R Hymes

  • Angela P Campbell

  • Adrienne G Randolph

  • Respiratory Syncytial Virus - Pediatric Intensive Care (RSV-PIC) Investigators

  • Merry Tomcany

  • Kelly N Michelson

  • Heather E Price

  • Ronald C Sanders

  • Lexie Dixon

  • Katri V Typpo

  • Ilana Harwayne-Gidansky

  • Suden Kucukak

  • SabrinaR Chen

  • Eve Listerud

  • Ofelia Vargas-Shiraishi

  • Betty Oberle

  • Frances Zorensky

  • Rachel Mansour

  • Jaycee Jumarang

  • Marla Johnston

  • Jenny L Bush

  • Shawn Dickey

  • Shannon Hill

  • Melissa Sullivan

  • Abigail Kietzman

  • Candice Colston

  • Meghan Murdock

  • Heather Kelley

  • Laura Wright-Sexton

  • Maygan Martin

  • Lora Martin

  • Lacy Malloch

  • Kayla Patterson

  • Cameron Sanders

  • Chelsea Rohlfs

  • Marilyn Rice

  • Miranda Howard

  • Makayla Murphy

  • Vijaya L Soma

  • Adam J Ratner

  • Megan J Job

  • Colleen Mennie

  • Kamala Simkhada

  • Kristina A Betters

  • Haya Hayek

  • Molly Maranto

  • Aubrie Waters

  • Maggie Flowers

  • Kevin Havlin

  • Jamie Furlong-Dillard

  • Melissa Porter

  • Jennifer Nason

  • Madison Ray

  • Kristen Gossett

  • Hillary Crandall

  • Evan Heller

  • Jennifer Foley

  • Rajashri Rasal

  • Christine Marlow

  • Anurithi Senthil

  • Kimberly Myers

  • Betsy Tudor

  • Amanda Adler

  • Nereyda Garcia

  • Natalie Treister

  • Patrick S McQuillen

  • Kathleen Sun

  • Denise Villarreal-Chico

  • Sophia Kainaroi

  • John V Williams

  • January 15, 2025

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Objective:

To evaluate clinical improvement and deterioration of RSV-related critical illness using the Clinical Progression Scale–Pediatrics (CPS-Ped) and identify predictors of failure to improve by day 7, highlighting the significance of these predictors.

Key Findings:
  • Of 585 hospitalized infants, 23.6% received invasive mechanical ventilation (IMV) and 1 infant died.
  • 35% of infants failed to clinically improve by day 7, which is significant and associated with age <3 months, prematurity, underlying respiratory conditions, and IMV in the first 24 hours.
  • CPS-Ped can effectively capture disease severity and track clinical improvement in infants with RSV-related critical illness.
Interpretation:

CPS-Ped is a promising tool for evaluating clinical outcomes in infants with severe RSV infections, potentially aiding in clinical trials and public health surveillance by providing a comprehensive measure of disease severity.

Limitations:
  • Study limited to infants hospitalized in PICUs, which may not represent all RSV cases.
  • Data collected through medical record review may have inherent biases.
  • Sample size may limit generalizability of findings.
Conclusion:

CPS-Ped can facilitate the assessment of clinical improvement in RSV-related critical illness and support future clinical trials, emphasizing its importance in clinical practice.

Original Source(s)

Assessing Clinical Improvement of Infants Hospitalized for Respiratory Syncytial Virus–Related Critical Illness

  • by Shannon B Leland, Laura D Zambrano, Steven J Staffa, Elizabeth R McNamara, Margaret M Newhams, Natasha Halasa, Justin Z Amarin, Laura S Stewart, Steven L Shein, Christopher L Carroll, Julie C Fitzgerald, Marian G Michaels, Katherine Bline, Melissa L Cullimore, Laura Loftis, Vicki L Montgomery, Asumthia S Jeyapalan, Pia S Pannaraj, Adam J Schwarz, Natalie Z Cvijanovich, Matt S Zinter, Aline B Maddux, Melania M Bembea, Katherine Irby, Danielle M Zerr, Joseph D Kuebler, Christopher J Babbitt, Mary G Gaspers, Ryan Nofziger, Michele Kong, Bria M Coates, Jennifer E Schuster, Shira J Gertz, Elizabeth H Mack, Benjamin R White, Helen Harvey, Charlotte V Hobbs, Heda Dapul, Andrew D Butler, Tamara T Bradford, Courtney M Rowan, Kari Wellnitz, Mary Allen Staat, Cassyanne L Aguiar, Saul R Hymes, Angela P Campbell, Adrienne G Randolph, Respiratory Syncytial Virus - Pediatric Intensive Care (RSV-PIC) Investigators, Merry Tomcany, Kelly N Michelson, Heather E Price, Ronald C Sanders, Lexie Dixon, Katri V Typpo, Ilana Harwayne-Gidansky, Suden Kucukak, SabrinaR Chen, Eve Listerud, Ofelia Vargas-Shiraishi, Betty Oberle, Frances Zorensky, Rachel Mansour, Jaycee Jumarang, Marla Johnston, Jenny L Bush, Shawn Dickey, Shannon Hill, Melissa Sullivan, Abigail Kietzman, Candice Colston, Meghan Murdock, Heather Kelley, Laura Wright-Sexton, Maygan Martin, Lora Martin, Lacy Malloch, Kayla Patterson, Cameron Sanders, Chelsea Rohlfs, Marilyn Rice, Miranda Howard, Makayla Murphy, Vijaya L Soma, Adam J Ratner, Megan J Job, Colleen Mennie, Kamala Simkhada, Kristina A Betters, Haya Hayek, Molly Maranto, Aubrie Waters, Maggie Flowers, Kevin Havlin, Jamie Furlong-Dillard, Melissa Porter, Jennifer Nason, Madison Ray, Kristen Gossett, Hillary Crandall, Evan Heller, Jennifer Foley, Rajashri Rasal, Christine Marlow, Anurithi Senthil, Kimberly Myers, Betsy Tudor, Amanda Adler, Nereyda Garcia, Natalie Treister, Patrick S McQuillen, Kathleen Sun, Denise Villarreal-Chico, Sophia Kainaroi, John V Williams

  • January 15, 2025

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