The Cortical Asymmetry Index for subtyping dementia patients - Summary - MDSpire

The Cortical Asymmetry Index for subtyping dementia patients

  • By

  • Agnès Pérez-Millan

  • Uma Maria Lal-Trehan Estrada

  • Neus Falgàs

  • Núria Guillén

  • Sergi Borrego-Écija

  • Jordi Juncà-Parella

  • Beatriz Bosch

  • Adrià Tort-Merino

  • Jordi Sarto

  • Josep Maria Augé

  • Anna Antonell

  • Núria Bargalló

  • Raquel Ruiz-García

  • Laura Naranjo

  • Mircea Balasa

  • Albert Lladó

  • Roser Sala-Llonch

  • Raquel Sánchez-Valle

  • February 11, 2025

  • 0 min

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Objective:

To evaluate the Cortical Asymmetry Index (CAI) as a tool for differentiating between dementia types, particularly FTD and AD, and to track the progression of neurodegeneration, with a focus on specific subtypes of FTD.

Key Findings:
  • CAI can differentiate between FTD and AD patients, providing a potential diagnostic tool.
  • Among FTD phenotypes, svPPA exhibited the highest asymmetry, indicating its distinct clinical profile.
  • Cortical asymmetry measures correlate with cognitive decline and fluid biomarkers, suggesting their utility in monitoring disease progression.
Interpretation:

Cortical asymmetry serves as a promising biomarker for distinguishing between dementia subtypes and monitoring disease progression.

Limitations:
  • Computational complexity and higher data requirements for CAI calculation may limit its widespread application in clinical settings.
  • Potential interpretation challenges of probabilistic measures could affect the reliability of CAI results.
Conclusion:

The CAI is a valuable tool for improving the accuracy of dementia diagnosis and understanding neurodegenerative progression, with implications for clinical practice and future research.

Original Source(s)

The Cortical Asymmetry Index for subtyping dementia patients

  • by Agnès Pérez-Millan, Uma Maria Lal-Trehan Estrada, Neus Falgàs, Núria Guillén, Sergi Borrego-Écija, Jordi Juncà-Parella, Beatriz Bosch, Adrià Tort-Merino, Jordi Sarto, Josep Maria Augé, Anna Antonell, Núria Bargalló, Raquel Ruiz-García, Laura Naranjo, Mircea Balasa, Albert Lladó, Roser Sala-Llonch, Raquel Sánchez-Valle

  • February 11, 2025

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