Which biomarkers predict risk better in women? - Summary - MDSpire

Which biomarkers predict risk better in women?

  • By

  • Lale Tokgözoğlu

  • Meral Kayıkçıoğlu

  • October 29, 2025

  • 0 min

Share

Objective:

To highlight the critical need for sex-specific biomarkers in cardiovascular risk prediction for women, addressing the unique biological and clinical factors that influence their cardiovascular health.

Key Findings:
  • LDL cholesterol (LDL-C) showed no prognostic value in the studied high-risk population, raising questions about its role in women.
  • Remnant cholesterol (RC) predicted major adverse cardiovascular events (MACE) in both sexes, highlighting its potential as a universal marker.
  • ApoA-1 and triglyceride/HDL-cholesterol ratio were significant predictors only in women, indicating the need for gender-specific assessments.
  • CERT1 and CERT2 scores were predictive only in men, suggesting a gap in understanding their applicability to women.
Interpretation:

The lack of predictive value for LDL-C may reflect the population context rather than LDL biology, emphasizing the urgent need for alternative biomarkers tailored to women's cardiovascular health.

Limitations:
  • The study population was predominantly elderly, high-risk, and statin-treated, which may limit the generalizability of the findings.
  • Key biomarkers like Lp(a) and non-HDL-C were not measured, potentially overlooking critical risk factors.
  • Potential calibration bias due to male-dominant derivation and validation cohorts may weaken the predictive performance for women.
Conclusion:

ApoB or non-HDL-C should complement LDL-C in assessing cardiovascular risk in women, reinforcing the need for updated clinical guidelines.

Original Source(s)

Which biomarkers predict risk better in women?

  • by Lale Tokgözoğlu, Meral Kayıkçıoğlu

  • October 29, 2025

Related Content

AD Not Linked to Early CV Risk Markers

Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.

Immune cells and high-density lipoprotein cholesterol derivative markers mediate the impact of hypertriglyceridemia on hyperuricemia in diabetes mellitus

Vitamin D: The Answer May Be Genetic

A post hoc D2d analysis found vitamin D3 supplementation was linked to lower diabetes risk only among patients with ApaI AC or CC genotypes.