Atherogenic index of plasma and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus: a retrospective cross-sectional study - Summary - MDSpire
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Atherogenic index of plasma and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus: a retrospective cross-sectional study
To examine the relationship between the Atherogenic Index of Plasma (AIP) and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM).
Key Findings:
A dose-response trend was observed between increasing AIP quartiles and greater severity of coronary stenosis (P for trend <0.01).
Median AIP was significantly higher in patients with severe stenosis (≥70%) compared to those with non-obstructive disease (0.14 vs. 0.05, P<0.001).
AIP was independently associated with obstructive stenosis (≥50%), with an odds ratio of 3.93 (95% CI: 1.70–9.62).
The area under the ROC curve (AUC) for AIP was 0.598, significantly better than LDL cholesterol (0.481, P = 0.032) and HDL cholesterol (0.384, P<0.001).
Interpretation:
Limitations:
The study is retrospective and cross-sectional, limiting causal inferences.
The cohort was limited to a single center, which may affect generalizability.
