To assess in-hospital mortality of glioblastoma patients admitted to ICU requiring invasive mechanical ventilation (IMV) and analyze reasons for ICU admission and survival outcomes after discharge.
Key Findings:
Identified 33 patients with a mean age of 60.3 years; 33% were female.
Main reasons for ICU admission were infections (34.3%), status epilepticus (31.4%), and elevated intracranial pressure (22.9%).
Some patients had newly diagnosed glioblastoma during ICU stay, with significant cases of elevated intracranial pressure, impacting post-discharge outcomes.
Interpretation:
The study highlights the critical need for structured data on glioblastoma patients in ICU settings, particularly regarding morbidity and mortality, to guide treatment decisions effectively.
Limitations:
Retrospective design may introduce bias.
Small sample size limits generalizability.
Data collection limited to specific centers may not represent broader populations.
Potential confounding factors affecting outcomes were not fully explored.
Conclusion:
This study provides essential insights into the outcomes of glioblastoma patients requiring IMV in ICU, emphasizing the importance of tailored treatment approaches and ongoing assessment of patient status to improve clinical outcomes.
by Bernhard Neumann, Julia Onken, Nicole König, Henning Stetefeld, Sebastian Luger, Anna-Luisa Luger, Felix Schlachetzki, Ralf Linker, Peter Hau, Elisabeth Bumes
