To evaluate the risk of developing specific nonskeletal complications, including diabetes mellitus, dyslipidemia, urinary stones, and cataracts, in patients with thyroid cancer and hypoparathyroidism.
Key Findings:
TC with hypoP group showed significantly higher risks of diabetes mellitus (HR 1.31, 95% CI 1.01-1.68), dyslipidemia (HR 1.29, 95% CI 1.06-1.57), urinary stones (HR 1.61, 95% CI 1.00-2.57), and cataracts (HR 1.50, 95% CI 1.15-1.95) compared to controls.
Hypertension risk was higher in the TC with hypoP group compared to TC without hypoP (HR 1.39, 95% CI 1.00-1.93).
Increased urinary stone risk was noted in women, while cataract risk increased in patients aged over 50.
Interpretation:
Patients with thyroid cancer and hypoparathyroidism are at increased risk for specific nonskeletal complications, particularly older adults and women, highlighting the need for targeted monitoring and management strategies in clinical practice.
Limitations:
Retrospective design may limit causal inferences and introduce biases.
Potential confounding factors, such as comorbidities and treatment variations, were not fully accounted for in the analysis.
Conclusion:
The findings underscore the importance of monitoring and managing nonskeletal complications in thyroid cancer patients with hypoparathyroidism, and further prospective studies are warranted to validate these associations.
