To outline patterns of international cooperation, identify significant research themes, and evaluate the alignment of scientific output with the global distribution of HIV/HBV disease burden.
Key Findings:
Yearly publication volume increased consistently, with a notable rise in citations post-2017.
Research contributions were predominantly from affluent nations, particularly the US and Western Europe.
Emerging research themes shifted from antiviral therapy to immune-related outcomes, highlighting CD4+ T-cell dysfunction and immune dysregulation.
Interpretation:
The transition from treatment-centric to immunology-focused research reflects a growing recognition of immune dysregulation's role in HIV/HBV co-infection outcomes.
Limitations:
Discrepancies exist between high disease burden areas and those advancing immunological research.
Low- and middle-income countries face challenges in screening and treatment access.
Conclusion:
Enhanced locally driven, immunology-centric research and comprehensive immune-monitoring methodologies are essential for improving clinical outcomes in HIV/HBV co-infected individuals.
