Objective:

To evaluate the predictive power of routinely obtained demographic, clinical, inflammatory, and nutritional parameters for assessing acute cholecystitis severity, excluding TG18-defining variables.

Approach:

Key Findings:

• 1,330 patients were included after excluding 570 due to missing data or predefined clinical exclusion criteria.
• Biochemical and hematological parameters were analyzed to predict the severity of acute cholecystitis.
• The CRP-to-albumin ratio (CAR) was identified as a significant inflammatory biomarker in the multivariable analysis.

Interpretation:

The study aimed to identify easily accessible clinical features and laboratory parameters that can predict the severity of acute cholecystitis.

Limitations:

• Retrospective design may introduce biases.
• Exclusion of patients with concomitant infections or malignancies limits generalizability.
• No a priori power calculation was performed.

Conclusion:

The study highlights the potential of using standard admission metrics to predict severe acute cholecystitis.

Attribution Notice

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