Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle - Summary - MDSpire

Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle

  • By

  • Huan Wang

  • Luhui Li

  • Dingyuan Tu

  • Ping Shen

  • Zheyao Song

  • Mengjiao An

  • Xudong Li

  • Qi Ji

  • Peng Chen

  • Rongjun Cui

  • June 11, 2026

  • 0 min

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Objective:

To identify differential chromatin regulators (CRs) gene expression in breast cancer (BRCA) and investigate the biological function of HMGB3 using specific methods.

Approach:
    Key Findings:
    • Eleven CRs were identified and used to create a prognostic model that accurately predicts overall survival (OS).
    • Low-risk patients exhibited significantly higher immune cell infiltration.
    • HMGB3 expression levels were closely linked to BRCA.
    Interpretation:

    Limitations:
    • The study relies on bioinformatics analysis and requires further clinical sample verification.
    • The prognostic model's applicability to diverse populations needs to be assessed.
    Conclusion:

Original Source(s)

Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle

  • by Huan Wang, Luhui Li, Dingyuan Tu, Ping Shen, Zheyao Song, Mengjiao An, Xudong Li, Qi Ji, Peng Chen, Rongjun Cui

  • June 11, 2026

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