Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth - Summary - MDSpire

Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth

  • By

  • Michelle C. Hunsche

  • Anat Zaidman-Zait

  • Melissa Olana

  • Peter Szatmari

  • Teresa Bennett

  • Eric Duku

  • Stelios Georgiades

  • Isabel M. Smith

  • Lonnie Zwaigenbaum

  • Mayada Elsabbagh

  • Tracy Vaillancourt

  • Rachael Bedford

  • Connor M. Kerns

  • May 5, 2026

  • 0 min

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Objective:

To examine joint trajectories of anxiety and depression symptoms in autistic youth from ages 7 to 16, emphasizing the importance of understanding these trajectories for early detection and intervention.

Key Findings:
  • Anxiety symptoms remained stable from childhood into adolescence, while depression symptoms increased on average.
  • Significant individual variability in trajectories of anxiety and depression was observed.
  • Greater autistic traits and emotional reactivity correlated with higher initial anxiety and depression symptoms.
  • Stronger communication ability was linked to higher initial anxiety but a decrease in anxiety symptoms over time, suggesting a complex relationship.
Interpretation:

The study highlights the need for joint monitoring of anxiety and depression symptoms in autistic youth, as their trajectories are interconnected and may inform early detection and intervention strategies, with implications for clinical practice.

Limitations:
  • Reliance on caregiver reports may introduce bias.
  • The sample may not be representative of all autistic youth.
  • Potential caregiver bias in symptom reporting.
Conclusion:

Understanding the concurrent development of anxiety and depression symptoms in autistic adolescents is crucial for identifying at-risk individuals and tailoring interventions.

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