Indocyanine green combined with autologous blood and methylene blue for pulmonary nodules localization in 272 cases: a novel localization method - Summary - MDSpire

Indocyanine green combined with autologous blood and methylene blue for pulmonary nodules localization in 272 cases: a novel localization method

  • By

  • Quan Du

  • Zijie Wang

  • Jian Chen

  • Hong Chen

  • Yuanrong Tu

  • Min Lin

  • Jianfeng Chen

  • August 11, 2025

  • 0 min

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Objective:

To evaluate the efficacy of a novel localization method using indocyanine green (ICG) mixed with autologous blood and methylene blue for preoperative localization of pulmonary nodules, highlighting its potential impact on surgical outcomes.

Key Findings:
  • The combination of ICG, autologous blood, and methylene blue improved localization success rates, with a reported increase of X% (insert specific data).
  • The method demonstrated safety and efficacy in guiding thoracoscopic surgeries.
  • Postoperative assessments confirmed adequate marker distribution with minimal complications.
Interpretation:

The novel localization method using ICG with autologous blood and methylene blue is a promising approach for enhancing the visibility of small pulmonary nodules during surgery, potentially transforming surgical practices.

Limitations:
  • The study was conducted at a single institution, which may limit generalizability and introduce biases.
  • The sample size, while substantial, may not capture all variations in nodule characteristics.
Conclusion:

The study supports the use of ICG combined with autologous blood and methylene blue as an effective and economical method for preoperative localization of pulmonary nodules, potentially improving surgical outcomes and warranting further research.

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